Kimchi (Korean fermented vegetable) attenuates liver damage through improving lipid metabolism and suppressing apoptosis in high cholesterol diet-fed mice (2024)


2nd International Conference on Food Chemistry & Nutrition

July 24-26, 2017 Vancouver, Canada

Minji Woo, Mijeong Kim, Serim Kim, Jeong Sook Noh and Yeong Ok Song

Pusan National University, Republic of Korea
Tongmyong University, Republic of Korea

Posters & Accepted Abstracts: J Exp Food Chem

Abstract :

High cholesterol diet (HCD) is known to cause hepatic steatosis. Apoptosis is a major cell death pathway hepatocyte which occursin a wide variety of liver diseases. Kimchi, a Korean traditional fermented vegetable, demonstrated to have antioxidative, antiatherogenic,and anti-cancer properties. This study investigated whether kimchi methanol extracts (KME) affects lipid metabolismand apoptosis in the liver of HCD-fed mice. Animals fed HCD for 8 weeks with oral administration of KME (200 mg/kg bw/day) ordistilled water as a vehicle (n = 10 for each group). Compared with the control group, the kimchi group decreased the hepatic proteinexpression for fatty acid synthesis (SREBP-1, ACC�±, FAS) and cholesterol synthesis (SREBP-2, HMGCR), whereas increased thatfor fatty acid oxidation (PPAR-�±, CPT1, ACOX1) and cholesterol export (CYP7A1) (all for P<0.05). Additionally, hepatic proteinexpression for proapoptotic factors (Bax, p-JNK, caspase-3, -9) was decreased, while that for anti-apoptotix factors (Bcl2, cIAP) waselevated in the kimchi group (all for P<0.05). Furthermore, histological analysis (oil red O, H&E, TUNEL staining) in the liver tissueshowed that hepatic steatosis, inflammation, and apoptosis in the kimchi group were less severe. In conclusion, HCD-induced liverdamage can be alleviated by kimchi administration via improving lipid metabolism and suppressing apoptosis.

Biography :

Yeong Ok Song has completed her MS from California University and PhD from Pusan National University. She is now the professor of Dept. Food science and nutrition in Pusan National University. She has made reserach achievements, focusing on the lipid lowering and anti-atherogenic effects of functional foods, and kimchi in particular. She has published more than 50 papers for kimchi in reputed journals. Moreover, her excellence in research has been recognized by the Academic Society, by which she was awarded ‘The Greatest Achievement in Research in 2015.

Email: yosong@pusan.ac.kr

Kimchi (Korean fermented vegetable) attenuates liver damage through improving lipid metabolism and suppressing apoptosis in high cholesterol diet-fed mice (2024)

FAQs

What Korean food removes plaque from arteries? ›

Beneficial effects of kimchi, a Korean fermented vegetable food, on pathophysiological factors related to atherosclerosis.

Is kimchi bad for your liver? ›

Kimchi also helped sustain healthy liver function. Levels of AST and ALT, which are indicators of liver damage, were both lower in the kimchi group. Elevated AST and ALT levels are generally associated with damaged liver cells caused by hepatitis, fatty liver, and hepatocirrhosis.

Is kimchi bad for high cholesterol? ›

Probiotics may improve heart health by reducing cholesterol and inflammation. The fiber, antioxidants, and nutrients in kimchi can also help lower blood sugar and cholesterol levels, which can boost heart health. Early research suggests kimchi may strengthen your immune system.

What happens if you eat kimchi every day? ›

Numerous studies have shown that a diet high in fermented foods, such as kimchi, has proven health benefits, such as increasing microbiome diversity and reducing inflammation. Another study, published in April in the Journal of Ethnic Foods, found that kimchi can be an effective treatment aid for obesity.

What will dissolve plaque in arteries? ›

There is no fast way to unclog arteries once plaque has built up. The best evidence for stabilizing and regressing plaque is with a combination of cholesterol-lowering medications, such as statins along with healthy lifestyle habits.

Can anything reverse plaque buildup in arteries? ›

"Unfortunately, plaque buildup cannot be fully reversed," says Dr. Rozo. It's a reality that emphasizes the importance of preventing atherosclerosis in the first place. But while existing deposits may not be reversible, effective management of coronary artery disease can help prevent further plaque buildup.

Who should not eat kimchi? ›

Another consideration is the high sodium content in kimchi. People at risk of high blood pressure might have concerns about the high salt content of this food.

What is the side effect of eating too much kimchi? ›

What happens when you eat too much kimchi? Since kimchi is fermented and spicy, you might experience uncomfortable gastric repercussions. Usually those with IBS or other gastrointestinal issues are more prone to sensitivity, especially since kimchi is also spicy.

Is kimchi bad for gut health? ›

Along with fiber, vitamins, and minerals, kimchi contains natural probiotic bacteria. If you eat them regularly, the probiotics in fermented foods can be beneficial to your gut microbiome. Studies suggest that eating kimchi on a daily basis could help to improve some digestive problems.

Is store-bought kimchi healthy? ›

Kimchi has an excellent nutritional profile. The dish is low in calories but packed with nutrients like iron, folate, and vitamins B6 and K.

What time of day should I eat kimchi? ›

As far as timing? It's most optimal to eat enzyme rich fermented food at the beginning of the meal, so they can begin the work of helping digestion as soon as they land in the stomach.

How long does kimchi last in the fridge? ›

If you have store-bought kimchi that's been opened, it will be good for 3-4 days at room temperature and up to 6 months when refrigerated. Signs of your kimchi going bad include mold growth, an alcoholic smell, and an extremely sour taste.

What is the best food to remove plaque from arteries? ›

Here are eight foods you can work into your diet to keep plaque out of those blood vessels.
  1. Fish. ...
  2. Seeds & Nuts. ...
  3. Green Vegetables. ...
  4. Olive Oil. ...
  5. Berries. ...
  6. Avocado. ...
  7. Broccoli. ...
  8. Chocolate.

What is a nutrient that dissolves arterial plaque? ›

Optimal Vitamin K2 intake is crucial to avoid the calcium plaque buildup of atherosclerosis, thus keeping the risk and rate of calcification as low as possible.

What can I drink to clear clogged arteries? ›

What drink cleans arteries? Some research suggests that herbal teas such as green tea may help treat clogged arteries. However, a person may need to make other dietary and lifestyle changes, as well as taking other preventive steps to prevent further plaque buildup.

Does turmeric remove plaque from arteries? ›

Heart Disease

Early studies suggested that turmeric may help prevent atherosclerosis, the buildup of plaque that can block arteries and lead to heart attack or stroke. In animal studies, an extract of turmeric lowered cholesterol levels and kept LDL (bad) cholesterol from building up in blood vessels.

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